Inflammation and cardiovascular disease: are marine phospholipids the answer?,Food & Function

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Inflammation and cardiovascular disease: are marine phospholipids the answer?
Food & Function ( IF 5.1 ) Pub Date : 2020-04-03 , DOI: 10.1039/c9fo01742a
Ronan Lordan ₁ , Shane Redfern ₂ , Alexandros Tsoupras ₃ , Ioannis Zabetakis ₃

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Since the discovery that Greenlandic Innuits had a lower risk of developing cardiovascular diseases (CVD) due to their diet of fish and as a consequence high polyunsaturated fatty acids (PUFA) intake, scientific interest in the therapeutic value of n-3 PUFA such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) has grown. It is well-accepted that fish consumption is associated with the prevention of inflammation and CVD. As a result, fish oil supplements and nutraceuticals are widely consumed. Conversely, recent meta-analyses have cast doubt over the benefits n-3 PUFA due to heterogenous outcomes of numerous randomized controlled trials. However, the majority of clinical studies conducted have used n-3 PUFA supplements in their neutral forms as free fatty acids or bound to triacylglycerides (TAG) or ethyl esters. Current research indicates that n-3 PUFA bound to polar lipids (PL) such as phospholipids seem to exert differential bioavailability and biological effects upon consumption in contrast to neutral forms of n-3 PUFA. In this review, we discuss the promising health benefits of marine PL rich in n-3 PUFA that seem to go beyond those of neutral n-3 PUFA. However, further intensive research is required to discern the full extent of the biological activities of marine n-3 PL and their potential use in functional foods and nutraceuticals.

中文翻译：

炎症和心血管疾病：海洋磷脂是答案吗？

自从格陵兰的因纽特人发现鱼食并因此摄入高多不饱和脂肪酸（PUFA）从而降低罹患心血管疾病（CVD）的风险以来，人们对n-3 PUFA（如二十碳五烯酸）的治疗价值产生了科学兴趣酸（EPA）和二十二碳六烯酸（DHA）的生长。食用鱼类与预防发炎和CVD相关联是众所周知的。结果，鱼油补充剂和营养食品被广泛食用。相反，由于许多随机对照试验的结果不一致，最近的荟萃分析对n-3 PUFA的益处产生了怀疑。但是，进行的大多数临床研究均使用中性形式的n-3 PUFA补充剂作为游离脂肪酸或与三酰甘油酯（TAG）或乙酯结合。当前的研究表明，与中性形式的n-3 PUFA相比，与极性脂质（PL）（例如磷脂）结合的n-3 PUFA似乎在食用时发挥了不同的生物利用度和生物效应。在这篇综述中，我们讨论了富含n-3 PUFA的海洋PL的有益健康益处，似乎超出了中性n-3 PUFA的益处。但是，需要进一步的深入研究来确定海洋n-3 PL的生物活性的全部范围，以及它们在功能性食品和营养保健品中的潜在用途。我们讨论了富含n-3 PUFA的海洋PL的有益健康益处，似乎超出了中性n-3 PUFA的益处。但是，需要进一步的深入研究来确定海洋n-3 PL的生物活性的全部范围，以及它们在功能性食品和营养保健品中的潜在用途。我们讨论了富含n-3 PUFA的海洋PL的有益健康益处，似乎超出了中性n-3 PUFA的益处。然而，需要进一步的深入研究来识别海洋n-3 PL的生物活性的全部范围，以及它们在功能性食品和营养保健品中的潜在用途。

更新日期：2020-04-03

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