Osteopromotive carbon dots promote bone regeneration through the PERK-eIF2α-ATF4 pathway.,Biomaterials Science

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Osteopromotive carbon dots promote bone regeneration through the PERK-eIF2α-ATF4 pathway.
Biomaterials Science ( IF 5.8 ) Pub Date : 2020-05-19 , DOI: 10.1039/d0bm00424c
Nianqiang Jin ₁ , Nuo Jin ₁ , Zilin Wang ₂ , Lili Liu ₂ , Lin Meng ₂ , Daowei Li ₃ , Xing Li ₁ , Dabo Zhou ₄ , Jie Liu ₅ , Wenhuan Bu ₆ , Hongchen Sun ₁ , Bai Yang ₇

Affiliation

Bone defects are still an unsolved clinical issue that must be overcome. Carbon dots have shown very promising effects in biological therapy. In the current study, we explored their effects on osteogenesis. Furthermore, we revealed the mechanisms in order to develop novel therapeutic approaches to manage the bone defect. For this study, ascorbic acid carbon dots (CDs) were created by a one-step microwave-assisted method. Results showed that the CDs effectively enhanced matrix mineralization, promoted osteogenic differentiation in vitro, and promoted new bone regeneration in the skull defect model in vivo. Furthermore, our data demonstrated that the ER stress and PERK-eIF2α-ATF4 pathway were activated by the CD-induced increase in intracellular calcium. Taken together, our findings suggest that the PERK pathway plays a critical role in CD-induced osteogenic differentiation, and the CDs created herein have the potential to be used to repair bone defects in clinical practice.

中文翻译：

促骨碳点通过PERK-eIF2α-ATF4途径促进骨骼再生。

骨缺损仍然是必须解决的尚未解决的临床问题。碳点在生物治疗中显示出非常有希望的效果。在当前的研究中，我们探讨了它们对成骨的影响。此外，我们揭示了这些机制，以便开发出新颖的治疗方法来管理骨缺损。对于本研究，通过一步微波辅助方法创建了抗坏血酸碳点（CD）。结果表明，在体内颅骨缺损模型中，CD可有效地增强基质矿化，促进成骨分化并促进新的骨再生。此外，我们的数据表明，ER应激和PERK-eIF2α-ATF4途径被CD诱导的细胞内钙增加激活。在一起

更新日期：2020-04-03

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