An efficient eco-friendly catalyst-free three-component domino multicyclization for the synthesis of new spirobicyclic oxazolidinedione containing cyclopentenone moieties has been established by mixing amines, β-dicarbonyl compounds and N,N′-dimethylalloxan in water at room temperature. This domino process involves multiple reactions such as enamination/aldol-like reaction/Stork enamine annulation/intramolecular cyclization under mild conditions.

中文翻译：

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三组分反应中底物控制的选择性开关：在水中连续合成螺恶唑烷二酮-环戊烯酮和羟基烯胺巴比妥酸盐

通过在室温下将胺、β-二羰基化合物和N , N'-二甲基四氧嘧啶在水中混合，建立了一种高效、环保、无催化剂的三组分多米诺多环化反应，用于合成含有环戊烯酮部分的新型螺双环恶唑烷二酮。该多米诺骨牌过程涉及温和条件下的烯胺化/类羟醛反应/Stork烯胺成环/分子内环化等多种反应。