“Calcium hydroxide [Ca(OH)₂]” is a medicament frequently used for antimicrobial purposes in endodontic procedures, or it is used as a toxic-waste adsorbent in industry. Ca(OH)₂ particles produced through conventional methods are size untunable and have a wide size distribution and polygonal shape. In this paper, a novel and facile approach involving template-mediated synthesis and two-step ion exchange is proposed for uniform size Ca(OH)₂ composite particles generation. “Sodium-alginate (Na-alginate)” was used as a precursor, and monodisperse Na-alginate emulsions were formed through needle droplet or droplet microfluidic technology. After the first ion exchange step with the Ca²⁺ ions, “calcium-alginate (Ca-alginate)” particles were obtained. The Ca-alginate particles were intermediate reaction products and were designed to be the templates for ensuring the spherical shape and size of products. The OH⁻ ions were used for the second ion exchange step to fabricate Ca(OH)₂ composite particles. The results revealed that the Ca(OH)₂ composite particles were size tunable, had a spherical shape, and were monodisperse (with a relative standard deviation of less than 8%). The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay revealed that the Ca(OH)₂ composite particles were potential biocompatible materials.

中文翻译：

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利用两步离子交换反应轻松合成高度可调的单分散氢氧化钙复合颗粒

“氢氧化钙[Ca(OH) ₂ ]”是一种在牙髓手术中经常用于抗菌目的的药物，或者在工业中用作有毒废物的吸附剂。通过常规方法生产的Ca(OH) ₂颗粒尺寸不可调，并且具有宽的尺寸分布和多边形形状。在本文中，提出了一种涉及模板介导合成和两步离子交换的新颖而简便的方法，用于生成均匀尺寸的 Ca(OH) ₂复合颗粒。以“海藻酸钠（Na-alginate）”为前驱体，通过针滴或微滴微流控技术形成单分散的海藻酸钠乳液。在与 Ca ^{2+进行第一个离子交换步骤后}离子，得到“海藻酸钙（Ca-alginate）”颗粒。海藻酸钙颗粒是中间反应产物，被设计为确保产品球形和尺寸的模板。OH ^-离子用于第二个离子交换步骤以制备Ca(OH) ₂复合颗粒。结果表明，Ca(OH) ₂复合颗粒尺寸可调，呈球形，单分散（相对标准偏差小于8%）。3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) 测定表明 Ca(OH) ₂复合颗粒是潜在的生物相容性材料。