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Bone apatite anisotropic structure control via designing fibrous scaffolds
RSC Advances ( IF 3.9 ) Pub Date : 2020-4-2 , DOI: 10.1039/d0ra01295e Sungho Lee 1, 2 , Fukue Nagata 1 , Katsuya Kato 1 , Takayoshi Nakano 2
RSC Advances ( IF 3.9 ) Pub Date : 2020-4-2 , DOI: 10.1039/d0ra01295e Sungho Lee 1, 2 , Fukue Nagata 1 , Katsuya Kato 1 , Takayoshi Nakano 2
Affiliation
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Bone tissue has an anisotropic structure, associated with the collagen fibrils' orientation and the c-axis direction of the bone apatite crystal. The bone regeneration process comprises two main phases: bone mineral density restoration (bone quantity), and subsequent recovery of bone apatite c-axis orientation (bone quality). Bone quality is the determinant factor for mechanical properties of bone. Control of osteoblast alignment is one of the strategies for reconstructing bone quality since the collagen/apatite matrix orientation in calcified tissues is dependent on the osteoblast orientation. In this work, fibrous scaffolds designed for reconstruction of bone quality via cell alignment control was investigated. The fibrous scaffolds were fabricated using the electrospinning method with poly(lactic acid) at various fiber collecting speeds. The degree of fiber alignment in the prepared fibrous scaffolds increased with increasing fiber collecting speed, indicating that the fibers were oriented in a single direction. The alignment of osteoblasts on the fibrous scaffolds as well as the subsequent apatite c-axis orientation increased with increasing fiber collecting speed. We successfully controlled cell alignment and apatite c-axis orientation using the designed morphology of fibrous scaffolds. To the best of our knowledge, this is the first report demonstrating that adjusting the degree of fiber orientation for fibrous scaffolds can manipulate the regeneration of bone quality.
中文翻译：
通过设计纤维支架控制骨磷灰石各向异性结构
骨组织具有各向异性结构，与胶原原纤维的取向和骨磷灰石晶体的c轴方向有关。骨再生过程包括两个主要阶段：骨矿物质密度恢复（骨量）和随后骨磷灰石c轴方向的恢复（骨质量）。骨质量是骨力学性能的决定因素。成骨细胞排列的控制是重建骨质量的策略之一，因为钙化组织中的胶原蛋白/磷灰石基质的取向取决于成骨细胞的取向。在这项工作中，设计用于重建骨质量的纤维支架通过研究了细胞比对控制。使用聚乳酸的静电纺丝方法以不同的纤维收集速度制造纤维支架。制备的纤维支架中的纤维排列程度随着纤维收集速度的增加而增加，表明纤维以单一方向取向。成骨细胞在纤维支架上的排列以及随后的磷灰石c轴取向随着纤维收集速度的增加而增加。我们成功控制了细胞排列和磷灰石c使用设计的纤维支架形态的轴取向。据我们所知，这是第一份证明调整纤维支架的纤维取向程度可以控制骨质量再生的报告。
更新日期：2020-04-02
中文翻译：
通过设计纤维支架控制骨磷灰石各向异性结构
骨组织具有各向异性结构，与胶原原纤维的取向和骨磷灰石晶体的c轴方向有关。骨再生过程包括两个主要阶段：骨矿物质密度恢复（骨量）和随后骨磷灰石c轴方向的恢复（骨质量）。骨质量是骨力学性能的决定因素。成骨细胞排列的控制是重建骨质量的策略之一，因为钙化组织中的胶原蛋白/磷灰石基质的取向取决于成骨细胞的取向。在这项工作中，设计用于重建骨质量的纤维支架通过研究了细胞比对控制。使用聚乳酸的静电纺丝方法以不同的纤维收集速度制造纤维支架。制备的纤维支架中的纤维排列程度随着纤维收集速度的增加而增加，表明纤维以单一方向取向。成骨细胞在纤维支架上的排列以及随后的磷灰石c轴取向随着纤维收集速度的增加而增加。我们成功控制了细胞排列和磷灰石c使用设计的纤维支架形态的轴取向。据我们所知，这是第一份证明调整纤维支架的纤维取向程度可以控制骨质量再生的报告。
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