Micro-flow synthesis of β-amino acid derivatives via a rapid dual activation approach.,Chemical Communications

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Micro-flow synthesis of β-amino acid derivatives via a rapid dual activation approach.
Chemical Communications ( IF 4.3 ) Pub Date : 2020-04-03 , DOI: 10.1039/d0cc01403f
Naoto Sugisawa ₁ , Hiroyuki Nakamura , Shinichiro Fuse

Affiliation

Rapid dual activation (≤3.3 s) of both β-amino acid N-carboxy anhydride and alkyl chloroformate for the synthesis of a β-amino acid-derived scaffold was demonstrated. The key to success was the use of rapid mixing enabled by using a micro-flow reactor. The one-flow synthesis of 22 β-amino acid derivatives was achieved.

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