Decreased lung function is associated with elevated ferritin but not iron or transferrin saturation in 42,927 healthy Korean men: A cross-sectional study.,PLOS ONE

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Decreased lung function is associated with elevated ferritin but not iron or transferrin saturation in 42,927 healthy Korean men: A cross-sectional study.
PLOS ONE ( IF 2.9 ) Pub Date : 2020-04-02 , DOI: 10.1371/journal.pone.0231057
Jonghoo Lee ₁ , Hye Kyeong Park ₂ , Min-Jung Kwon ₃ , Soo-Youn Ham ₄ , Joon Mo Kim ₅ , Si-Young Lim ₆ , Jae-Uk Song ₆

Affiliation

Objectives

Though elevated ferritin level and decreased lung function both predispose people to cardio-metabolic disease, few reports have investigated the association between them. Furthermore, it remains unclear whether the association reflects a change in iron stores or an epiphenomenon reflecting metabolic stress. Therefore, we looked for possible associations between ferritin, iron, and transferrin saturation (TSAT) and lung function to clarify the role of iron-related parameters in healthy men.

Methods

We conducted a cohort study of 42,927 healthy Korean men (mean age: 38.6 years). Percent predicted forced expiratory volume in one second (FEV1%) and forced vital capacity (FVC%) were categorized into quartiles. Adjusted odds ratios (aORs) and 95% confidence intervals (using the highest quartile as reference) were calculated for hyperferritinemia, high iron, and high TSAT after controlling for potential confounders.

Results

The median ferritin level was 199.8 (141.5–275.6) ng/mL. The prevalence of hyperferritinemia (defined as >300 ng/mL) was 19.3%. Subjects with hyperferritinemia had lower FEV1% and FVC% than those with normal ferritin level with a slight difference, but those were statistically significant (99.22% vs.99.61% for FEV1%, p = 0.015 and 98.43% vs. 98.87% for FVC, p = 0.001). However, FEV1/FVC ratio was not significantly different between groups (P = 0.797). Compared with the highest quartile, the aORs for hyperferritinemia across decreasing quartiles were 1.081 (1.005–1.163), 1.100 (1.007–1.200), and 1.140 (1.053–1.233) for FEV1% (p for trend = 0.007) and 1.094 (1.018–1.176), 1.101 (1.021–1.188), and 1.150 (1.056–1.252) for FVC% (p for trend = 0.001). However, neither FEV1% nor FVC% was associated with iron or TSAT.

Conclusions

Hyperferritinemia was associated with decreased lung function in healthy Korean men, but iron and TSAT were not. Longitudinal follow-up studies are required to validate our findings.

中文翻译：

一项横断面研究显示，在42927名健康的韩国男性中，肺功能下降与铁蛋白升高有关，但与铁或转铁蛋白饱和度无关。

目标

尽管铁蛋白水平升高和肺功能下降都使人容易患上心脏代谢疾病，但很少有报道调查它们之间的关系。此外，还不清楚该关联是否反映铁储量的变化或反映代谢应激的表观现象。因此，我们寻找铁蛋白，铁和转铁蛋白饱和度（TSAT）与肺功能之间的可能联系，以阐明健康男性中铁相关参数的作用。

方法

我们对42,927名健康的韩国男性（平均年龄：38.6岁）进行了队列研究。一秒内预测的强制呼气量百分比（FEV1％）和强制肺活量（FVC％）分为四分位数。在控制了潜在的混杂因素后，计算出高铁蛋白血症，高铁和高TSAT的校正比值比（aOR）和95％置信区间（使用最高四分位数作为参考）。

结果

铁蛋白中位数为199.8（141.5–275.6）ng / mL。高铁蛋白血症（定义为> 300 ng / mL）的患病率为19.3％。高铁蛋白血症的受试者的FEV1％和FVC％低于正常铁蛋白水平的受试者，但有轻微差异，但具有统计学意义（FEV1％的受试者为99.22％vs .99.61％，p = 0.015和98.43％vs。FVC为98.87％，p = 0.001）。但是，两组之间的FEV1 / FVC比率无显着差异（P = 0.797）。与最高四分位数相比，四分位数递减的高铁蛋白血症的aOR为FEV1％（趋势p = 0.007）和1.094（1.018–1.018）分别为1.081（1.005-1.163），1.100（1.007-1.200）和1.140（1.053-1.233）。 FVC％（1.176），1.11（1.021–1.188）和1.150（1.056–1.252）（趋势p = 0.001）。但是，FEV1％和FVC％均与铁或TSAT无关。