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Evaluation of weight retention four weeks after delivery as a risk factor for gestational diabetes mellitus in a subsequent pregnancy.
PLOS ONE ( IF 2.9 ) Pub Date : 2020-04-02 , DOI: 10.1371/journal.pone.0231018
Satoshi Shinohara 1 , Atsuhito Amemiya 1 , Motoi Takizawa 1
Affiliation  

Aim

We aimed to assess the association between postpartum weight retention (PPWR) in the fourth week after delivery and the risk of gestational diabetes mellitus (GDM) in a subsequent pregnancy.

Methods

We performed a retrospective cohort study of the obstetric records of women who gave birth to their second singleton between 32 and 41 weeks of gestation at the National Hospital Organization Kofu National Hospital between January 2013 and September 2019. The exclusion criteria were missing data, twin pregnancy, diabetes in pregnancy, and delivery before 22 weeks in the first pregnancy. We calculated PPWR as the BMI 4 weeks after the first birth minus the BMI before the first pregnancy and grouped the subjects into the stable PPWR (gain of <1 BMI unit) and non-stable PPWR groups (gain of ≥1 BMI units). We used the χ2 test and multivariable logistic regression analysis to investigate the association between weight retention at the postpartum checkup and GDM.

Results

We included 566 women in this study (mean age, 31.7±4.8 years; mean maternal pre-pregnancy BMI, 21.3±3.5 kg/m2; term delivery, n = 544 [96.1%]). The overall prevalence of GDM during the second pregnancy was 7.4% (42/566), and 33.9% (192/566) of women had stable PPWR. Non-stable PPWR was not significantly associated with GDM in the second pregnancy (adjusted odds ratio, 1.93; 95% confidence interval, 0.84–4.46) after controlling for each variable.

Conclusion

PPWR measured in the fourth week after delivery was not associated with an increased risk of GDM in the second pregnancy.



中文翻译:


评估分娩后四周的体重保留作为随后妊娠中妊娠期糖尿病的危险因素。


 目的


我们的目的是评估产后第四周的产后体重滞留(PPWR)与随后怀孕时患妊娠糖尿病(GDM)的风险之间的关系。

 方法


我们对 2013 年 1 月至 2019 年 9 月期间在国立甲府国立医院在妊娠 32 至 41 周期间生下第二个单胎的妇女的产科记录进行了回顾性队列研究。排除标准为缺失数据、双胎妊娠、妊娠期糖尿病以及第一次妊娠22周前分娩。我们将 PPWR 计算为第一胎出生后 4 周的 BMI 减去第一次怀孕前的 BMI,并将受试者分组为稳定 PPWR(<1 id=6>2 检验增益和多变量逻辑回归分析,以研究体重保持与体重之间的关联)在产后检查和GDM。

 结果


我们在这项研究中纳入了 566 名女性(平均年龄,31.7±4.8 岁;平均母亲孕前 BMI,21.3±3.5 kg/m 2 ;足月分娩,n = 544 [96.1%])。第二次妊娠期间 GDM 的总体患病率为 7.4%(42/566),33.9%(192/566)的女性 PPWR 稳定。在控制每个变量后,不稳定的 PPWR 与第二次妊娠时的 GDM 没有显着相关性(调整优势比,1.93;95% 置信区间,0.84-4.46)。

 结论


产后第四周测量的 PPWR 与第二次妊娠时 GDM 风险增加无关。

更新日期:2020-04-03
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