Over a century of cancer research: Inconvenient truths and promising leads.,PLOS Biology

当前位置： X-MOL 学术 › PLOS Biol. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Over a century of cancer research: Inconvenient truths and promising leads.
PLOS Biology ( IF 7.8 ) Pub Date : 2020-04-01 , DOI: 10.1371/journal.pbio.3000670
Carlos Sonnenschein _{1,

2} , Ana M Soto _{1,

2}

Affiliation

Despite over a century of intensive efforts, the great gains promised by the War on Cancer nearly 50 years ago have not materialized. Since 1999, we have analyzed the lack of progress in explaining and "curing" cancer by examining the merits of the premises that determine how cancer is understood and treated. Our ongoing critical analyses have aimed at clarifying the sources of misunderstandings at the root of the cancer puzzle while providing a plausible and comprehensive biomedical perspective as well as a new theory of carcinogenesis that is compatible with evolutionary theory. In this essay, we explain how this new theory, the tissue organization field theory (TOFT), can help chart a path to progress for cancer researchers by explaining features of cancer that remain unexplainable from the perspective of the still hegemonic somatic mutation theory (SMT) and its variants. Of equal significance, the premises underlying the TOFT offer new perspectives on basic biological phenomena.

中文翻译：

一个多世纪的癌症研究：难以忽视的真相和有希望的线索。

尽管经过一个多世纪的努力，近50年前抗癌战争所承诺的巨大成果仍未实现。自 1999 年以来，我们通过检验决定如何理解和治疗癌症的前提的优点，分析了解释和“治愈”癌症方面缺乏进展的情况。我们正在进行的批判性分析旨在澄清癌症难题根源上的误解根源，同时提供合理且全面的生物医学视角以及与进化论兼容的新的致癌理论。在本文中，我们解释了组织组织场理论（TOFT）这一新理论如何通过解释从仍然占主导地位的体细胞突变理论（SMT）的角度仍然无法解释的癌症特征，帮助癌症研究人员绘制出一条进步之路。）及其变体。同样重要的是，TOFT 的前提为基本生物现象提供了新的视角。

更新日期：2020-04-01

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南11