Abstract

Background

Zika virus (ZIKV) was discovered over 70 years ago in East Africa, but little is known about its circulation and pathogenesis there.

Methods

We screened 327 plasma samples collected 2–12 months after febrile illness in Western and coastal Kenya (1993–2016) for binding and neutralizing antibodies to distinguish ZIKV and dengue virus (DENV) responses, which we found were common in coastal Kenya.

Results

Two cases had durable ZIKV-specific antibodies and 2 cases had ZIKV antibodies at similar levels as DENV antibodies.

Conclusions

This suggests low-level ZIKV circulation in Kenya over 2 decades and sets a baseline for future surveillance efforts in East Africa.

中文翻译：

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寨卡病毒在肯尼亚西部和沿海低水平传播。

摘要

背景

寨卡病毒 (ZIKV) 于 70 多年前在东非被发现，但对其在那里的传播和发病机制知之甚少。

方法

我们筛选了在肯尼亚西部和沿海地区（1993-2016 年）发热后 2-12 个月收集的 327 份血浆样本中的结合和中和抗体，以区分 ZIKV 和登革热病毒 (DENV) 反应，我们发现这在肯尼亚沿海地区很常见。

结果

2 例具有持久的 ZIKV 特异性抗体，2 例具有与 DENV 抗体水平相似的 ZIKV 抗体。

结论

这表明肯尼亚 20 多年来存在低水平 ZIKV 传播，并为东非未来的监测工作设定了基线。