Canfam_GSD: De novo chromosome-length genome assembly of the German Shepherd Dog (Canis lupus familiaris) using a combination of long reads, optical mapping, and Hi-C.,GigaScience

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Canfam_GSD: De novo chromosome-length genome assembly of the German Shepherd Dog (Canis lupus familiaris) using a combination of long reads, optical mapping, and Hi-C.
GigaScience ( IF 11.8 ) Pub Date : 2020-04-01 , DOI: 10.1093/gigascience/giaa027
Matt A Field _{1,

2} , Benjamin D Rosen ₃ , Olga Dudchenko _{4,

5,

6} , Eva K F Chan _{7,

8} , Andre E Minoche , Richard J Edwards ₉ , Kirston Barton _{7,

10} , Ruth J Lyons ₇ , Daniel Enosi Tuipulotu ₉ , Vanessa M Hayes _{7,

10,

11} , Arina D Omer _{4,

5} , Zane Colaric _{4,

5} , Jens Keilwagen ₁₂ , Ksenia Skvortsova ₇ , Ozren Bogdanovic _{7,

9} , Martin A Smith _{7,

10} , Erez Lieberman Aiden _{4,

5,

6,

13,

14} , Timothy P L Smith ₁₅ , Robert A Zammit ₁₆ , J William O Ballard ₉

Affiliation

Centre for Tropical Bioinformatics and Molecular Biology, Australian Institute of Tropical Health and Medicine, James Cook University, Smithfield Road, Cairns, QLD 4878, Australia.
John Curtin School of Medical Research, Australian National University, Garran Rd, Canberra, ACT 2600, Australia.
Animal Genomics and Improvement Laboratory, Agricultural Research Service USDA, Baltimore Ave, Beltsville, MD 20705, USA.
The Center for Genome Architecture, Department of Molecular and Human Genetics, Baylor College of Medicine, Baylor Plaza, Houston, TX 77030, USA.
Department of Computer Science, Rice University, Main St, Houston, TX 77005, USA.
Center for Theoretical and Biological Physics, Rice University, Main St, Houston, TX 77005, USA.
Garvan Institute of Medical Research, Victoria Street, Darlinghurst, NSW 2010, Australia.
St Vincent's Clinical School, University of New South Wales Sydney, Victoria Street, Darlinghurst NSW 2010, Australia.
School of Biotechnology and Biomolecular Sciences, UNSW Sydney, High St, Kensington, NSW 2052, Australia.
Faculty of Medicine, UNSW Sydney, High St, Kensington, NSW 2052, Australia.
Central Clinical School, University of Sydney, Parramatta Road, Camperdown, NSW 2050, Australia.
Julius Kühn-Institut, Erwin-Baur-Str. 27, 06484 Quedlinburg, Germany.
Broad Institute of MIT and Harvard, Main St, Cambridge, MA 02142, USA.
Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, ShanghaiTech University, Huaxia Middle Rd, Pudong 201210, China.
US Meat Animal Research Center, Agricultural Research Service USDA, Rd 313, Clay Center, NE 68933, USA.
Vineyard Veterinary Hospital, Windsor Rd, Vineyard, NSW 2765, Australia.

The German Shepherd Dog (GSD) is one of the most common breeds on earth and has been bred for its utility and intelligence. It is often first choice for police and military work, as well as protection, disability assistance, and search-and-rescue. Yet, GSDs are well known to be susceptible to a range of genetic diseases that can interfere with their training. Such diseases are of particular concern when they occur later in life, and fully trained animals are not able to continue their duties.

中文翻译：

Canfam_GSD：结合长读长、光学图谱和 Hi-C 对德国牧羊犬（Canis lupusamilis）进行从头染色体长度基因组组装。

德国牧羊犬（GSD）是地球上最常见的品种之一，因其实用性和智力而被培育。它通常是警察和军事工作以及保护、残疾人援助和搜救的首选。然而，众所周知，GSD 很容易受到一系列遗传疾病的影响，这些疾病可能会干扰他们的训练。此类疾病在生命后期发生时尤其令人担忧，并且经过充分训练的动物无法继续履行其职责。

更新日期：2020-04-17

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