Organoid models of childhood kidney tumours.,Nature Reviews Urology

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Organoid models of childhood kidney tumours.
Nature Reviews Urology ( IF 12.1 ) Pub Date : 2020-04-02 , DOI: 10.1038/s41585-020-0315-y
Ariadne H A G Ooms _{1,

2} , Camilla Calandrini _{1,

2} , Ronald R de Krijger _{1,

3} , Jarno Drost _{1,

2}

Affiliation

Paediatric kidney tumours comprise many different subtypes, each being heterogeneous in their cellular as well as genetic composition. Advances in the past decade in 3D culture models create new opportunities for the generation of preclinical models capturing this phenotypic and genetic heterogeneity, potentially enabling the generation of patient-tailored therapies.

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