Non-coding RNAs (ncRNAs) are indispensable for CD4+ T cell differentiation and functions. By directly or indirectly regulating immune gene expression, ncRNAs give flexible instructions to guide the biological processes of CD4+ T cells and play a vital role in maintaining immune homeostasis. However, the dysfunction of ncRNAs alters the gene expression profiles, disturbs the normal biological processes of CD4+ T cells, and leads to the functional changes of CD4+ T cells, which is an underlying cause of systemic lupus erythematosus (SLE). In this review, we focus on the recent advances in the roles of ncRNAs in CD4+ T cell functions and differentiation, as well as their potential applications in the diagnosis and treatment of SLE.

中文翻译：

---

CD4 + T细胞中的非编码RNA：系统性红斑狼疮发病机理的新见解。

非编码RNA（ncRNA）对于CD4 + T细胞的分化和功能必不可少。通过直接或间接调节免疫基因的表达，ncRNA提供了灵活的指导，以指导CD4 + T细胞的生物学过程，并在维持免疫稳态方面起着至关重要的作用。但是，ncRNA的功能异常会改变基因表达谱，扰乱CD4 + T细胞的正常生物学过程，并导致CD4 + T细胞的功能改变，这是系统性红斑狼疮（SLE）的根本原因。在这篇综述中，我们着眼于ncRNA在CD4 + T细胞功能和分化中的作用的最新进展，以及它们在SLE的诊断和治疗中的潜在应用。