Blood glucose homeostasis and insulin signaling pathway regulation take a vital role in the management of diabetes mellitus. Our present was designed to explore the mechanism of the blood homeostasis, regulation of oxidative stress and insulin signaling pathway by guava leaf extract (GLE). Diabetes mellitus was induced in male albino Wistar by streptozotocin (STZ) (Single dose-40 mg/kg b.w.). As an extension STZ rats received GLE (GLE; 200 mg/kg b.w). At the end of the study the lipid peroxidation products, antioxidants, insulin signaling genes were analyzed. Treatment with GLE resulted in decreased plasma and skeletal muscle lipid peroxidation markers, increased antioxidants, and improved insulin signaling genes. GLE treatment helps to maintain blood homeostasis alleviates oxidative stress and regulates the insulin signaling genes in skeletal muscle. Overall the results suggest GLE treatment regulates blood glucose, inhibits oxidative stress, and importantly it regulates insulin signaling pathway genes in skeletal muscle. Further studies on the GLE role in other important pathways can add additional strength to the claim that GLE is a strong anti-diabetic candidate.

中文翻译：

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番石榴叶提取物通过激活大鼠骨骼肌中的PI3K / AKT信号传导来改善STZ诱导的糖尿病。

血糖稳态和胰岛素信号通路调节在糖尿病的管理中起着至关重要的作用。本研究旨在探讨番石榴叶提取物（GLE）的血液稳态，氧化应激调节和胰岛素信号通路的机制。链脲佐菌素（STZ）（单剂量40 mg / kg bw）在雄性白化病Wistar中诱发糖尿病。作为扩展，STZ大鼠接受GLE（GLE； 200 mg / kg bw）。在研究结束时，分析了脂质过氧化产物，抗氧化剂，胰岛素信号转导基因。GLE治疗可降低血浆和骨骼肌脂质过氧化标记，增加抗氧化剂和改善胰岛素信号转导基因。GLE治疗有助于维持血液稳态，减轻氧化应激并调节骨骼肌中的胰岛素信号基因。总体而言，结果表明GLE治疗可调节血糖，抑制氧化应激，并且重要的是它可调节骨骼肌中的胰岛素信号通路基因。关于GLE在其他重要途径中的作用的进一步研究可以为声称GLE是强抗糖尿病药的说法增加更多的优势。