Aim

A reticulin staining pattern (RSP) can be used for the differential diagnosis of endocrine gland lesions, as in the adrenal and hypophysis glands. We aimed to use RSP for the differential diagnosis of parathyroid gland lesions.

Materials and methods

In this study, we evaluated 97 parathyroid lesions in 85 patients, as well as 29 normal parathyroid glands. All sections were stained with a silver impregnation-based kit for the reticulin stain. The RSPs were classified as short thick fiber-, anastomosing- and nodular/alveolar-pattern. The dominant pattern was accepted as being greater than 50% in each section.

Results

Short thick fibers and anastomosing and nodular RSPs were seen in adenomas, but there was no alveolar pattern. Although nodular/alveolar patterns were seen in focal areas in hyperplasia, they never became the dominant pattern. Nodular dominant RSPs were seen in adenomas; however, nodular RSPs were not seen in hyperplasia in a dominant pattern (p = 0.049). While short thick fibers were not seen in normal glands, they could be seen in adenomas (p < 0.001) and in hyperplasia (p < 0.001).

Conclusion

RSPs can be used in the differential diagnosis of parathyroid lesions. While short thick reticular fibers support adenomas and hyperplasia rather than normal tissue, a nodular dominant pattern supports adenomas rather than hyperplasia.

中文翻译：

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网状蛋白染色模式在甲状旁腺良性病变的鉴别诊断中

目标

网状蛋白染色模式（RSP）可用于内分泌腺病变的鉴别诊断，如在肾上腺和垂体腺中。我们旨在将RSP用于甲状旁腺病变的鉴别诊断。

材料和方法

在这项研究中，我们评估了85例患者中的97处甲状旁腺病变以及29例正常的甲状旁腺。所有切片均用基于银浸渍的网状蛋白染色试剂盒进行染色。RSP分为短粗纤维状，吻合状和结节状/肺泡状。主导模式被认为是在每个部分中大于50％。

结果

腺瘤中可见短而粗的纤维，吻合和结节性RSP，但无牙槽花纹。尽管在增生的病灶部位可见结节状/肺泡型，但它们从未成为显性型。腺瘤中见结节性占优势的RSP。然而，在增生组织中未见明显的结节性RSP（p  = 0.049）。虽然在正常腺体中未见到短而粗的纤维，但在腺瘤（p  <0.001）和增生（p  <0.001）中可以看到它们。

结论

RSP可用于甲状旁腺病变的鉴别诊断。虽然短而粗的网状纤维支持腺瘤和增生，而不是正常组织，但结节状的主要形态支持腺瘤而不是增生。