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Correction: Mitosis-related phosphorylation of the eukaryotic translation suppressor 4E-BP1 and its interaction with eukaryotic translation initiation factor 4E (eIF4E).
Journal of Biological Chemistry ( IF 5.5 ) Pub Date : 2020-04-03 , DOI: 10.1074/jbc.aac120.013398
Rui Sun , Erdong Cheng , Celestino Velásquez , Yuan Chang , Patrick S. Moore

VOLUME 294 (2019) PAGES 11840–11852In this study on mitotic mRNA translation, the authors report on cloned HeLa cell lines that were generated by CRISPR/Cas9 EIF4EBP1 knockout and then stable substitutions with either the EIF4EBP1 WT or codon S83A mutations. During cell line verification surveillance performed after publication, the authors found that 293T cells had been used instead of HeLa cells and were mislabeled (both HeLa and 293T cell lines had been initially targeted for EIF4EBP1 knockout). None of the conclusions are changed by this error. The authors regret the confusion generated by mis-stating the cell line used in this study and affirm the importance of routine cell line verification.

中文翻译:

校正:真核翻译抑制剂4E-BP1的有丝分裂相关的磷酸化及其与真核翻译起始因子4E(eIF4E)的相互作用。

第294卷(2019)11840–11852页在有丝分裂mRNA翻译的这项研究中,作者报告了通过CRISPR / Cas9 EIF4EBP1敲除产生的克隆的HeLa细胞系,然后被EIF4EBP1 WT或密码子S83A突变稳定取代。在发表后进行的细胞系验证监视过程中,作者发现293T细胞已代替HeLa细胞被使用并被错误标记(HeLa和293T细胞系最初都被靶向EIF4EBP1敲除)。该错误不会更改任何结论。作者对由于误用本研究中使用的细胞系而产生的混乱感到遗憾,并确认了常规细胞系验证的重要性。
更新日期:2020-04-03
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