Synthetic molecular evolution of host cell-compatible, antimicrobial peptides effective against drug-resistant, biofilm-forming bacteria [Applied Biological Sciences],Proceedings of the National Academy of Sciences of the United States of America

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Synthetic molecular evolution of host cell-compatible, antimicrobial peptides effective against drug-resistant, biofilm-forming bacteria [Applied Biological Sciences]
Proceedings of the National Academy of Sciences of the United States of America ( IF 9.4 ) Pub Date : 2020-04-02
Charles G. Starr, Jenisha Ghimire, Shantanu Guha, Joseph P. Hoffmann, Yihui Wang, Leisheng Sun, Brooke N. Landreneau, Zachary D. Kolansky, Isabella M. Kilanowski-Doroh, Mimi C. Sammarco, Lisa A. Morici, William C. Wimley

Novel classes of antibiotics and new strategies to prevent and treat infections are urgently needed because the rapid rise in drug-resistant bacterial infections in recent decades has been accompanied by a parallel decline in development of new antibiotics. Membrane permeabilizing antimicrobial peptides (AMPs) have long been considered a potentially promising,...

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