Targeting the cholesterol biosynthetic pathway has become a mainstay for the treatment of ischemic heart disease (1). However, the importance of cholesterol metabolism is not just confined to atherosclerosis, as cholesterol is an essential component of membranes, a precursor for other metabolic pathways, and can fuel tumor growth (2). Understanding...

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角鲨烯和胆固醇在ER膜上处于平衡状态[评论]

靶向胆固醇的生物合成途径已成为治疗缺血性心脏病的主要手段（1）。然而，胆固醇代谢的重要性不仅限于动脉粥样硬化，因为胆固醇是膜的重要组成部分，是其他代谢途径的前体，并且可以促进肿瘤生长（2）。理解...