In bacteria, the first two steps of gene expression—transcription and translation—are spatially and temporally coupled. Uncoupling may lead to the arrest of transcription through RNA polymerase backtracking, which interferes with replication forks, leading to DNA double-stranded breaks and genomic instability. How transcription–translation coupling mitigates these conflicts is unknown. Here we...

中文翻译：

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核糖体通过物理地将RNA聚合酶从转录抑制中移出来重新激活转录[生物化学]

在细菌中，基因表达的前两个步骤-转录和翻译-在空间和时间上是耦合的。脱偶联可能导致通过RNA聚合酶回溯来阻止转录，这会干扰复制叉，导致DNA双链断裂和基因组不稳定。转录-翻译偶联如何减轻这些冲突是未知的。在这里，我们...