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Cancer epithelia-derived mitochondrial DNA is a targetable initiator of a paracrine signaling loop that confers taxane resistance [Cell Biology]
Proceedings of the National Academy of Sciences of the United States of America ( IF 9.4 ) Pub Date : 2020-04-01 Subhash Haldar, Rajeev Mishra, Sandrine Billet, Manish Thiruvalluvan, Veronica R. Placencio-Hickok, Anisha Madhav, Frank Duong, Bryan Angara, Priyanka Agarwal, Mourad Tighiouart, Edwin M. Posadas, Neil A. Bhowmick
Proceedings of the National Academy of Sciences of the United States of America ( IF 9.4 ) Pub Date : 2020-04-01 Subhash Haldar, Rajeev Mishra, Sandrine Billet, Manish Thiruvalluvan, Veronica R. Placencio-Hickok, Anisha Madhav, Frank Duong, Bryan Angara, Priyanka Agarwal, Mourad Tighiouart, Edwin M. Posadas, Neil A. Bhowmick
Stromal-epithelial interactions dictate cancer progression and therapeutic response. Prostate cancer (PCa) cells were identified to secrete greater concentration of mitochondrial DNA (mtDNA) compared to noncancer epithelia. Based on the recognized coevolution of cancer-associated fibroblasts (CAF) with tumor progression, we tested the role of cancer-derived mtDNA in a mechanism of paracrine...
中文翻译：
癌症上皮来源的线粒体DNA是旁分泌信号环的靶向启动子，赋予紫杉烷抗性[细胞生物学]
基质与上皮的相互作用决定了癌症的进展和治疗反应。与非癌上皮相比，前列腺癌（PCa）细胞分泌出更高浓度的线粒体DNA（mtDNA）。基于公认的癌症相关成纤维细胞（CAF）与肿瘤进展的协同进化，我们测试了癌症衍生的mtDNA在旁分泌机制中的作用...
更新日期：2020-04-03
中文翻译：
癌症上皮来源的线粒体DNA是旁分泌信号环的靶向启动子，赋予紫杉烷抗性[细胞生物学]
基质与上皮的相互作用决定了癌症的进展和治疗反应。与非癌上皮相比，前列腺癌（PCa）细胞分泌出更高浓度的线粒体DNA（mtDNA）。基于公认的癌症相关成纤维细胞（CAF）与肿瘤进展的协同进化，我们测试了癌症衍生的mtDNA在旁分泌机制中的作用...
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