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Vitamin B6 Fuels Acute Myeloid Leukemia Growth.
Trends in Cancer ( IF 14.3 ) Pub Date : 2020-04-02 , DOI: 10.1016/j.trecan.2020.03.005 Shuai Jiang 1
中文翻译:
维生素B6促进急性髓细胞性白血病的生长。
更新日期:2020-04-02
Trends in Cancer ( IF 14.3 ) Pub Date : 2020-04-02 , DOI: 10.1016/j.trecan.2020.03.005 Shuai Jiang 1
Affiliation
Mounting evidence indicates that vitamins C and D are linked to tumor growth, but the relevance of vitamin B6 remains uncertain. In a recent study, Chen et al. demonstrate that pyridoxal kinase promotes vitamin B6 phosphorylation, producing the active form pyridoxal 5′-phosphate, which regulates two key metabolic enzymes required for acute myeloid leukemia (AML) cell growth.
中文翻译:
维生素B6促进急性髓细胞性白血病的生长。
越来越多的证据表明,维生素C和D与肿瘤的生长有关,但维生素B6的相关性仍不确定。在最近的研究中,Chen等。证明吡ido醛激酶促进维生素B6磷酸化,产生活性形式的吡ido醛5'-磷酸,它调节急性髓细胞性白血病(AML)细胞生长所需的两种关键代谢酶。