Physical modification of Thai rice starch and its application as orodispersible film former.,Carbohydrate Polymers

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Physical modification of Thai rice starch and its application as orodispersible film former.
Carbohydrate Polymers ( IF 10.7 ) Pub Date : 2020-04-02 , DOI: 10.1016/j.carbpol.2020.116206
Ekapol Limpongsa ₁ , Napaphak Jaipakdee ₂

Affiliation

The objective of this study was to investigate the application of the physically modified rice starch (MRS) produced by alcoholic-alkaline (MRS-AA) and planetary ball-milling (MRS-BM) methods as an ODF film former. Rice starch was isolated from Thai rice grain. XRD and ATR-FTIR results confirmed crystallinity loss of MRS. MRS-AA exhibited prominently the greater swelling capacity, whereas MRS-BM exhibited prominently the greater cold water solubility. The starch-based orodispersible films (ODFs) with acceptable film and mechanical properties were successfully prepared using solvent casting method. MRS-based ODFs exhibited the greater flexible behaviors but lower disintegration time compared with the native system. Desloratadine loaded MRS-BM-based ODFs disintegrated within 62.3 ± 23.1 s, with more than 95% dissolution within 10 min. In conclusion, the ball-milling treatment resulted in the preferable MRS suitable for use as an ODF film former. This study therefore provides a glimpse into the use of physically modified starch as an ODF film former.

中文翻译：

泰国大米淀粉的物理改性及其在口分散成膜剂中的应用。

这项研究的目的是研究通过酒精碱性（MRS-AA）和行星球磨（MRS-BM）方法生产的物理改性大米淀粉（MRS）作为ODF成膜剂的应用。大米淀粉是从泰国大米中分离出来的。XRD和ATR-FTIR结果证实了MRS的结晶度损失。MRS-AA显着表现出更大的溶胀能力，而MRS-BM显着表现出更大的冷水溶解度。使用溶剂流延法成功制备了具有可接受的膜和机械性能的淀粉基口腔分散膜（ODF）。与本地系统相比，基于MRS的ODF表现出更大的灵活性，但分解时间更短。装载去氯雷他定的基于MRS-BM的ODF在62.3±23.1 s内崩解，在10分钟内溶出度超过95％。结论，球磨处理产生适合用作ODF成膜剂的优选的MRS。因此，这项研究提供了使用物理改性淀粉作为ODF成膜剂的一瞥。

更新日期：2020-04-03

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