Tablets are one of the most commonly used solid dosage forms taken by patients. The preparation of high-quality tablets requires an understanding of the preparation process and elucidation of how the physical and mechanical properties change as a function of the preparation process. This work aims to investigate the impact of microwave irradiation drying and conventional drying methods (including freeze, convective and vacuum drying) on the hardness, tensile strength and friability of tablets made from a multi-component formulation containing naproxen sodium, microcrystalline cellulose, and polyvinylpyrrolidone. The results show that tablets subjected to microwave drying had the second-highest tensile strength and hardness of 1.296 MPa and 67 N, respectively. The tablets subjected to vacuum drying had the lowest tensile strength and hardness of 1.21 MPa and 64 N, respectively. The friability index values for the tablets derived from the microwave and freeze-drying methods were <1%, while those for the tablets subjected to convective drying and vacuum drying methods were>1%. Microwave drying was observed to be an efficient method to produce naproxen sodium-containing tablets with satisfactory mechanical properties. These findings confirm that the drying method plays an essential role in the improvement or degradation of the mechanical properties of tablets.

片剂是患者服用的最常用的固体剂型之一。高质量片剂的制备需要了解制备过程，并阐明物理和机械性能如何随制备过程而变化。这项工作旨在研究微波辐照干燥和常规干燥方法（包括冷冻，对流和真空干燥）对由含有萘普生钠，微晶纤维素和聚乙烯吡咯烷酮的多组分制剂制成的片剂的硬度，拉伸强度和易碎性的影响。 。结果表明，经过微波干燥的片剂分别具有第二高的拉伸强度和硬度，分别为1.296 MPa和67N。经过真空干燥的片剂的最低拉伸强度和硬度为1。分别为21 MPa和64N。来自微波和冷冻干燥方法的片剂的易碎指数值＜1％，而经过对流干燥和真空干燥方法的片剂的易碎指数值＞ 1％。观察到微波干燥是生产具有令人满意的机械性能的含有萘普生钠的片剂的有效方法。这些发现证实，干燥方法在改善或降低片剂的机械性能中起着至关重要的作用。观察到微波干燥是生产具有令人满意的机械性能的含有萘普生钠的片剂的有效方法。这些发现证实，干燥方法在改善或降低片剂的机械性能中起着至关重要的作用。观察到微波干燥是生产具有令人满意的机械性能的含有萘普生钠的片剂的有效方法。这些发现证实，干燥方法在改善或降低片剂的机械性能中起着至关重要的作用。