Direct ink writing allows controlling the structure of tissue engineering scaffolds. The aim of this work was to study the effects of the in silico pattern design on the dimensional accuracy of tricalcium phosphate scaffolds and of the loading direction on the compressive strength and fracture modes. Regular and shifted scaffolds showed anisotropic shrinkage during drying and isotropic shrinkage during sintering. Shifted layers induced bending stresses when compressed longitudinally, resulting in lower compressive strength. The transverse Young’s modulus and compressive strength were higher than the longitudinal ones for both regular and shifted structures. Strand deflections were more pronounced in shifted structures. Finite element modelling suggested that such deflections considerably increased the effective transverse modulus of the shifted scaffolds, thus increasing the related compressive strength. In conclusion, shifted scaffolds performed similarly to regular ones in the transverse direction but were less mechanically reliable under the longitudinal direction.

直接墨水书写可以控制组织工程支架的结构。这项工作的目的是研究计算机模拟的影响图案设计对磷酸三钙支架的尺寸精度以及载荷方向的抗压强度和断裂模式的影响。规则的和移位的支架在干燥过程中表现出各向异性收缩，而在烧结过程中表现出各向同性收缩。当纵向压缩时，移位的层会引起弯曲应力，从而导致较低的压缩强度。对于规则结构和位移结构，横向杨氏模量和抗压强度均高于纵向。偏斜在位移的结构中更为明显。有限元建模表明，这种挠曲大大增加了移位后的脚手架的有效横向模量，从而增加了相关的抗压强度。结论，