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RGD-modified ZnO nanoparticles loaded with nitric oxide precursor for targeted cancer therapy
Chemical Physics Letters ( IF 2.8 ) Pub Date : 2020-04-02 , DOI: 10.1016/j.cplett.2020.137445
Huiyu Ding , Liying Wang , Lin Zhang , Baohua Zhu , Lili Hou , Guicheng Huang , Ziqing Xu

RGD-conjugated ZnO quantum dots (QDs) with phenylsulfonyl furoxan (PSF) loaded (PSF@ZnO-RGD) were prepared. ZnO QDs with amino groups exposed were synthesized, in which the NO donor PSF was entrapped by forming coordination bonds between Zn2+ ions and PSF. The conjugated RGD endowed the PSF@ZnO-RGD with tumor-targeting ability, which would decompose in response to lowered pH to release Zn2+ ions and the PSF. The intracellular glutathione triggered NO release from the PSF. Zn2+ ions and NO exerted combined inhibitory effects on cancer cells. This work gives new highlights into delivery of multiple agents for synergistic cancer therapy.



中文翻译:

RGD修饰的一氧化氮前体负载的ZnO纳米颗粒,用于靶向癌症治疗

制备了负载了苯磺酰基呋喃聚糖(PSF)(PSF @ ZnO-RGD)的RGD共轭ZnO量子点(QD)。合成了具有暴露的氨基的ZnO量子点,其中NO供体PSF通过在Zn 2+离子和PSF之间形成配位键而被捕获。共轭RGD赋予了PSF @ ZnO-RGD肿瘤靶向能力,该能力会随着pH降低而分解以释放Zn 2+离子和PSF。细胞内谷胱甘肽触发了PSF的NO释放。Zn 2+离子和NO对癌细胞具有联合抑制作用。这项工作为协同癌症治疗的多种药物的交付提供了新的亮点。

更新日期:2020-04-02
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