RGD-conjugated ZnO quantum dots (QDs) with phenylsulfonyl furoxan (PSF) loaded (PSF@ZnO-RGD) were prepared. ZnO QDs with amino groups exposed were synthesized, in which the NO donor PSF was entrapped by forming coordination bonds between Zn²⁺ ions and PSF. The conjugated RGD endowed the PSF@ZnO-RGD with tumor-targeting ability, which would decompose in response to lowered pH to release Zn²⁺ ions and the PSF. The intracellular glutathione triggered NO release from the PSF. Zn²⁺ ions and NO exerted combined inhibitory effects on cancer cells. This work gives new highlights into delivery of multiple agents for synergistic cancer therapy.

制备了负载了苯磺酰基呋喃聚糖（PSF）（PSF @ ZnO-RGD）的RGD共轭ZnO量子点（QD）。合成了具有暴露的氨基的ZnO量子点，其中NO供体PSF通过在Zn ²⁺离子和PSF之间形成配位键而被捕获。共轭RGD赋予了PSF @ ZnO-RGD肿瘤靶向能力，该能力会随着pH降低而分解以释放Zn ²⁺离子和PSF。细胞内谷胱甘肽触发了PSF的NO释放。Zn ²⁺离子和NO对癌细胞具有联合抑制作用。这项工作为协同癌症治疗的多种药物的交付提供了新的亮点。