Hollow mesoporous particles for drug delivery and cancer therapy have attracted significant attention over recent decades. Here, we develop a simple and highly efficient strategy for preparing fluorescent hollow mesoporous carbon spheres (HMCSs). Compared with typical carbon materials such as fullerene C60, carbon nanotubes, reduced graphene oxide, and carbon nanohorns; HMCSs showed fewer effects on cell cycle distribution and lower toxicity to cells. Ten different drugs were incorporated into the HMCSs, and the maximum loading efficiency reached 42.79 ± 2.7%. Importantly, microwaves were found to improve the photothermal effect generated by HMCSs when combined with 980-nm laser irradiation. The cell killing and tumor growth inhibition efficiencies of HMCSs and drug-loaded HMCSs under co-irradiation with laser and microwaves were significantly improved compared with those under laser irradiation alone. After local administration HMCSs were only distributed in tissue at the injection site. HMCSs showed almost no toxicity in mice after local injection and could be completely removed from the injection site.

中文翻译：

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荧光空心中孔碳球，用于通过980 nm激光和微波共同照射进行载药和肿瘤治疗。

在最近几十年中，用于药物输送和癌症治疗的中孔介孔颗粒引起了极大的关注。在这里，我们开发了一种简单高效的制备荧光空心中孔碳球（HMCSs）的策略。与典型的碳材料相比，例如富勒烯C60，碳纳米管，还原的氧化石墨烯和碳纳米角；HMCS对细胞周期分布的影响较小，对细胞的毒性较低。将十种不同的药物掺入HMCS中，最大加载效率达到42.79±2.7％。重要的是，发现微波可以改善HMCS与980 nm激光辐射结合产生的光热效应。与单独激光照射相比，HMCSs和载药的HMCSs在激光和微波共同照射下的细胞杀伤和肿瘤生长抑制效率显着提高。局部给药后，HMCS仅分布在注射部位的组织中。HMCS在局部注射后对小鼠几乎没有毒性，可以从注射部位完全清除。