Biological tubes form in a variety of shapes and sizes. Tubular topology of cells and tissues is a widely recognizable histological feature of multicellular life. Fluid secretion, storage, transport, absorption, exchange, and elimination-processes central to metazoans-hinge on the exquisite tubular architectures of cells, tissues, and organs. In general, the apparent structural and functional complexity of tubular tissues and organs parallels the architectural and biophysical properties of their constitution, i.e., cells and the extracellular matrix (ECM). Together, cellular and ECM dynamics determine the developmental trajectory, topological characteristics, and functional efficacy of biological tubes. In this review of tubulogenesis, we highlight the multifarious roles of ECM dynamics-the less recognized and poorly understood morphogenetic counterpart of cellular dynamics. The ECM is a dynamic, tripartite composite spanning the luminal, abluminal, and interstitial space within the tubulogenic realm. The critical role of ECM dynamics in the determination of shape, size, and function of tubes is evinced by developmental studies across multiple levels-from morphological through molecular-in model tubular organs.

中文翻译：

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小管发生中的细胞外基质动力学。

生物管形成各种形状和尺寸。细胞和组织的管状拓扑结构是多细胞生命的广泛公认的组织学特征。液体分泌、储存、运输、吸收、交换和消除过程是后生动物的核心过程，取决于细胞、组织和器官的精致管状结构。一般来说，管状组织和器官的明显结构和功能复杂性与其构成的结构和生物物理特性平行，即细胞和细胞外基质 (ECM)。细胞和 ECM 动力学共同决定了生物管的发育轨迹、拓扑特征和功能功效。在这篇关于肾小管发生的综述中，我们强调了 ECM 动力学的多种作用 - 细胞动力学的较少识别和理解的形态发生对应物。ECM 是一种动态的三方复合材料，跨越管腔领域内的管腔、管腔外和间质空间。ECM 动力学在确定管的形状、大小和功能方面的关键作用在多个层次的发育研究中得到证实 - 从形态学到分子模型管状器官。