Osteoarthritis (OA) is affecting large proportions of the population worldwide. So far, no effective disease modifying drug has been developed for this disease, limiting the therapeutic options to pain medications, physiotherapy and ultimately surgical approaches, mainly joint implant surgery. In vitro and animal studies have demonstrated that bisphosphonates have the potential to become effective modalities for the treatment of OA. This group of pharmacological agents modulates crucial aspects of OA pathogenesis (subchondral bone turnover and loss, bone marrow edema formation, cartilage degeneration and synovitis), and have shown clear efficacy in animal models of OA. Human studies have, however, so far been disappointing with only one of six clinical studies showing clear short-term efficacy. Possible reasons for these discrepancies will be discussed.

中文翻译：

---

双膦酸盐作为骨关节炎的治疗方式

骨关节炎 (OA) 正在影响全世界大部分人口。到目前为止，还没有针对这种疾病开发出有效的疾病改善药物，将治疗选择限制在止痛药、物理疗法和最终的手术方法，主要是关节植入手术。体外和动物研究表明，双膦酸盐有可能成为治疗 OA 的有效方式。这组药物调节 OA 发病机制的关键方面（软骨下骨转换和丢失、骨髓水肿形成、软骨变性和滑膜炎），并在 OA 动物模型中显示出明确的疗效。然而，迄今为止，人体研究令人失望，六项临床研究中只有一项显示出明显的短期疗效。