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Identification of Kidney Transplant Recipients with Coronavirus Disease 2019.
European Urology ( IF 25.3 ) Pub Date : 2020-04-02 , DOI: 10.1016/j.eururo.2020.03.030
Hui Zhang 1 , Yan Chen 2 , Quan Yuan 3 , Qiu-Xiang Xia 4 , Xian-Peng Zeng 4 , Jing-Tao Peng 4 , Jing Liu 4 , Xing-Yuan Xiao 4 , Guo-Song Jiang 4 , Han-Yu Xiao 4 , Liang-Bo Xie 4 , Jing Chen 4 , Jia-Li Liu 4 , Xiong Xiao 4 , Hua Su 5 , Chun Zhang 5 , Xiao-Ping Zhang 4 , Hua Yang 6 , Heng Li 4 , Zhen-Di Wang 4
Affiliation  

Coronavirus disease 2019 (COVID-19) is a novel and lethal infectious disease, posing a threat to global health security. The number of cases has increased rapidly, but no data concerning kidney transplant (KTx) recipients infected with COVID-19 are available. To present the epidemiological, clinical, and therapeutic characteristics of KTx recipients infected with COVID-19, we report on a case series of five patients who were confirmed as having COVID-19 through nucleic acid testing (NAT) from January 1, 2020 to February 28, 2020. The most common symptoms on admission to hospital were fever (five patients, 100%), cough (five patients, 100%), myalgia or fatigue (three patients, 60%), and sputum production (three patients, 60%); serum creatinine or urea nitrogen levels were slightly higher than those before symptom onset. Four patients received a reduced dose of maintenance immunosuppressive therapy during hospitalization. As of March 4, 2020 NAT was negative for COVID-19 in three patients twice in succession, and their computed tomography scans showed improved images. Although greater patient numbers and long-term follow-up data are needed, our series demonstrates that mild COVID-19 infection in KTx recipients can be managed using symptomatic support therapy combined with adjusted maintenance immunosuppressive therapy.



中文翻译:

2019 年冠状病毒病肾移植受者的鉴定。

2019冠状病毒病(COVID-19)是一种新型致命传染病,对全球卫生安全构成威胁。病例数量迅速增加,但没有关于感染 COVID-19 的肾移植 (KTx) 受者的数据。为了介绍感染了 COVID-19 的 KTx 接受者的流行病学、临床和治疗特征,我们报告了 2020 年 1 月 1 日至 2 月期间通过核酸检测 (NAT) 确认患有 COVID-19 的 5 名患者的病例系列2020年12月28日。入院时最常见的症状是发烧(5名患者,100%)、咳嗽(5名患者,100%)、肌痛或疲劳(3名患者,60%)和咳痰(3名患者,60%) %); 血清肌酐或尿素氮水平略高于症状出现前。四名患者在住院期间接受了减少剂量的维持免疫抑制治疗。截至 2020 年 3 月 4 日,三名患者的 NAT 检测结果连续两次呈 COVID-19 阴性,他们的计算机断层扫描显示图像有所改善。尽管需要更多的患者数量和长期随访数据,但我们的系列研究表明,可以使用对症支持治疗结合调整后的维持性免疫抑制治疗来控制 KTx 接受者的轻度 COVID-19 感染。

更新日期:2020-04-02
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