Fundamental Principles of the Thermodynamics and Kinetics of Protein Adsorption to Material Surfaces.,Colloids and Surfaces B: Biointerfaces

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Fundamental Principles of the Thermodynamics and Kinetics of Protein Adsorption to Material Surfaces.
Colloids and Surfaces B: Biointerfaces ( IF 5.4 ) Pub Date : 2020-04-01 , DOI: 10.1016/j.colsurfb.2020.110992
Robert A Latour ₁

Affiliation

Protein adsorption is important for essentially any process that involves the contact of a protein-containing solution and a material surface, with the resulting formation of the adsorbed layer of protein determined by the thermodynamics and kinetics of the system involved. This paper presents an overview of the fundamentals of these processes. First, the hierarchical structure of proteins and the types of bonding that stabilize a protein's native-state structure are presented. This section is then followed by a section presenting the thermodynamic driving forces that influence the way that proteins adsorb and conformationally change for three characteristically different types of surface chemistries: nonpolar (hydrophobic) surfaces, neutral hydrophilic surfaces, and charged surfaces. The final section of this paper addresses how kinetics and thermodynamics combine together to influence protein adsorption behavior, followed by concluding remarks.

中文翻译：

蛋白质吸附到材料表面的热力学和动力学的基本原理。

蛋白质吸附对于涉及含蛋白质溶液和材料表面接触的基本上任何过程都很重要，由此产生的蛋白质吸附层的形成由所涉及系统的热力学和动力学决定。本文概述了这些过程的基本原理。首先，介绍了蛋白质的层次结构和稳定蛋白质天然状态结构的键合类型。本节之后的一节介绍了影响蛋白质吸附和构象变化方式的热力学驱动力，这些驱动力是三种不同类型的表面化学特征：非极性（疏水）表面、中性亲水表面和带电表面。

更新日期：2020-04-03

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