Herein we demonstrate the successful application of reductive strategy in the asymmetric domino ring opening/cross-coupling reaction of prochiral cyclobutanones. Under the catalysis of a chiral nickel complex, various aryl iodide-tethered cyclobutanones were reacted with alkyl bromides as the electrophilic coupling partner, providing a variety of chiral indanones bearing a quaternary stereogenic center in highly enantioselective manner, which can be further converted to diverse benzene-fused cyclic compounds including indane, indene, dihydrocoumarin, and dihydroquinolinone. The preliminary mechanistic investigations support a mechanism involving Ni(I)-mediated enantiotopic C−C σ-bond activation of cyclobutanones as key elementary step in the catalytic cycle.

在此，我们展示了还原策略在前手性环丁酮的不对称多米诺开环/交叉偶联反应中的成功应用。在手性镍配合物的催化下，各种芳基碘连接的环丁酮与作为亲电偶联伙伴的烷基溴发生反应，以高度对映选择性的方式提供了各种带有季立体中心的手性茚满酮，这些手性茚满酮可以进一步转化为各种苯-稠环化合物，包括茚满、茚、二氢香豆素和二氢喹啉酮。初步的机理研究支持了一种机制，涉及 Ni(I) 介导的环丁酮对映体 C−C σ 键活化，作为催化循环中的关键基本步骤。