Bacterial gene expression depends on the allocation of limited transcriptional resources provided a particular growth rate and growth condition. Early studies in a few genes suggested this global regulation to generate a unifying hyperbolic expression pattern. Here, we developed a large-scale method that generalizes these experiments to quantify the response to growth of over 700 genes that a priori do not exhibit any specific control. We distinguish a core subset following a promoter-specific hyperbolic response. Within this group, we sort genes with regard to their responsiveness to the global regulatory program to show that those with a particularly sensitive linear response are located near the origin of replication. We then find evidence that this genomic architecture is biologically significant by examining position conservation of E. coli genes in 100 bacteria. The response to the transcriptional resources of the cell results in an additional feature contributing to bacterial genome organization.

细菌基因表达取决于特定转录速率和生长条件的有限转录资源的分配。早期对一些基因的研究表明，这种全局调节可产生统一的双曲线表达模式。在这里，我们开发了一种大规模的方法，可以对这些实验进行概括，以量化对先验先验的700多个基因生长的响应没有任何特定的控制。我们区分启动子特有的双曲线响应后的核心子集。在该组中，我们根据基因对全球监管计划的响应程度对基因进行分类，以显示线性响应特别敏感的基因位于复制起点附近。然后，我们通过检查E的位置保守性，发现该基因组结构在生物学上具有重要意义的证据。100种细菌中的大肠杆菌基因。对细胞转录资源的反应导致有助于细菌基因组组织的其他特征。