Endocrine disrupting chemicals (EDCs) are chemicals that can interfere with normal endocrine signals. Human exposure to EDCs is particularly concerning during vulnerable periods of life, such as pregnancy. However, often overlooked is the effect that EDCs may pose to the placenta. The abundance of hormone receptors makes the placenta highly sensitive to EDCs. We have reviewed the most recent advances in our understanding of EDC exposures on the development and function of the placenta such as steroidogenesis, spiral artery remodeling, drug-transporter expression, implantation and cellular invasion, fusion, and proliferation. EDCs reviewed include those ubiquitous in the environment with available human biomonitoring data. This review also identifies critical gaps in knowledge to drive future research in the field.

中文翻译：

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胎盘破坏：内分泌干扰化学物质与怀孕


内分泌干​​扰化学物质 (EDC) 是可以干扰正常内分泌信号的化学物质。人类在生命的脆弱时期（例如怀孕期间）接触 EDC 尤其令人担忧。然而，经常被忽视的是 EDC 可能对胎盘造成的影响。丰富的激素受体使得胎盘对 EDC 高度敏感。我们回顾了 EDC 暴露对胎盘发育和功能（如类固醇生成、螺旋动脉重塑、药物转运蛋白表达、植入和细胞侵袭、融合和增殖）影响的最新进展。审查的 EDC 包括环境中普遍存在且具有可用人类生物监测数据的 EDC。这篇综述还确定了知识方面的关键差距，以推动该领域的未来研究。