In this issue of Cell Stem Cell, Fumagalli et al. (2020) employ intravital microscopy of colorectal cancer organoid xenografts to investigate the cell of origin of metastases. While tumor-initiating cells are Lgr5⁺, most disseminated cancer cells are Lgr5⁻ and seed liver metastases in which Lgr5⁺ cells then appear, showing that bidirectional plasticity of phenotypic states drives metastasis.

中文翻译：

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运动可塑性：变形 Lgr5 细胞引发结直肠癌转移。

在本期《细胞干细胞》中，Fumagalli 等人。 (2020) 利用结直肠癌类器官异种移植物的活体显微镜来研究转移的细胞来源。虽然肿瘤起始细胞是 Lgr5 ⁺ ，但大多数播散性癌细胞是 Lgr5 ^- ，并且随后出现 Lgr5 ⁺细胞的种子肝转移，表明表型状态的双向可塑性驱动转移。