Asymmetric partitioning of damaged proteins is thought to play a key role in preserving stem cell function with age. In this issue of Cell Stem Cell, Morrow et al. (2020) show that vimentin recruits proteasome machinery to aggresomes to control NSC proteostasis during quiescence exit.

中文翻译：

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俘虏：波形蛋白笼在 NSC 激活期间捕获蛋白酶体

受损蛋白质的不对称分配被认为在随着年龄的增长保持干细胞功能方面发挥着关键作用。在本期《细胞干细胞》中，Morrow 等人。 (2020) 表明，波形蛋白将蛋白酶体机制招募到聚集体，以在静止退出期间控制 NSC 蛋白质稳态。