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Making the case for causality: what role do lung microbiota play in idiopathic pulmonary fibrosis?
European Respiratory Journal ( IF 16.6 ) Pub Date : 2020-04-01 , DOI: 10.1183/13993003.00318-2020
Robert P. Dickson , Sergio Harari , Martin Kolb

Though the notion of a “lung microbiome”, i.e. a complex community of microbes inhabiting and influencing the lower respiratory tract, is barely a decade old [1], there is nothing new about the idea that the lungs represent a crucial interface between us and the microbial universe we inhabit. Louis Pasteur demonstrated the presence of viable microbes in air [2], and one of his contemporaries calculated that healthy adults inhale between 1500 and 14 000 organisms each hour [3]. Yet more evidence that the lung microbiome plays a role in idiopathic pulmonary fibrosis. But how close are we to proving causality? An editorial from Dickson, Harari and Kolb in the ERJ. http://bit.ly/2Ps1ow4

中文翻译:

证明因果关系:肺微生物群在特发性肺纤维化中起什么作用?

尽管“肺微生物组”的概念,即栖息和影响下呼吸道的复杂微生物群落,只有十年的历史 [1],但关于肺代表我们和我们之间的关键界面的观点并没有什么新意。我们居住的微生物世界。Louis Pasteur 证明空气中存在活微生物 [2],他的一位同时代人计算出,健康成年人每小时吸入 1500 至 14000 个生物体 [3]。还有更多证据表明肺微生物组在特发性肺纤维化中起作用。但我们离证明因果关系有多近?ERJ 上 Dickson、Harari 和 Kolb 的社论。http://bit.ly/2Ps1ow4
更新日期:2020-04-01
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