There is growing recognition for the involvement of blood vessels in pulmonary diseases beyond the classical scope of pulmonary vascular medicine. As an example, reports have described a vascular phenotype of COPD, or have proposed a vanishing pulmonary capillary syndrome to underly emphysema [1, 2]. Although the number of clinical and epidemiological studies supporting such a vascular hypothesis of pulmonary disease is steadily growing, biological underpinning in clinical studies remains to be provided. VEGFR2 has a pivotal and specific role in vascular homeostasis and VEGFR2 mutations provide robust clinical evidence for direct involvement of a disturbed vasculature in a wide variety of lung diseases http://bit.ly/383ixTb

中文翻译：

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肺病血管消失：VEGFR2的作用

人们越来越认识到血管与肺血管疾病的关系超出了肺血管医学的经典范围。例如，有报告描述了 COPD 的血管表型，或提出肺毛细血管消失综合征是潜在的肺气肿 [1, 2]。尽管支持这种肺部疾病血管假说的临床和流行病学研究的数量正在稳步增长，但仍有待提供临床研究中的生物学基础。VEGFR2 在血管稳态中具有关键和特定的作用，VEGFR2 突变为紊乱的脉管系统直接参与多种肺部疾病提供了强有力的临床证据 http://bit.ly/383ixTb