l-Cysteine solubility in 12 monosolvents (water, methanol, ethanol, n-propanol, n-butanol, sec-butanol, isopropanol, isobutanol, ethyl acetate, 1,4-dioxane, acetonitrile, and acetone) and three binary solvents (water + methanol, water + ethanol, and water + isopropanol) was determined by the gravimetric method from 283.15 to 323.15 K under the atmospheric pressure. The solubility order in pure solvents was acetonitrile < isobutanol < ethyl acetate ≈ sec-butanol < n-butanol < 1,4-dioxane < isopropanol < n-propanol < ethanol < methanol < acetone < water, and it was positively related to the experimental temperature and solvent composition for all solvent systems. For polar protic solvents, the key factors influencing the solubility were the length of the carbon chain and the solvent properties. The effect of solvent–solvent and solvent–solute intermolecular interactions on the solubility behavior was analyzed by the KAT-LSER model. The modified Apelblat, Jouyban–Acree, and Apelblat–Jouyban–Acree models were used to correlate the solubility data, and the values calculated by the three thermodynamic models were found to agree well with the experimental data.

中文翻译：

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半胱氨酸在几种纯和二元溶剂体系中的溶解度的测定和相关性

升在12个monosolvents（水，甲醇，乙醇，半胱氨酸溶解度Ñ丙醇，Ñ丁醇，仲丁醇，异丙醇，异丁醇，乙酸乙酯，1,4-二恶烷，乙腈和丙酮）和三个二进制溶剂（水通过重量分析法在大气压下从283.15至323.15 K测定甲醇+（甲醇，水+乙醇和水+异丙醇）。在纯溶剂中的溶解度顺序为乙腈<异丁醇<乙酸乙酯≈秒-丁醇<正丁醇<1,4-二恶烷<异丙醇< n-丙醇<乙醇<甲醇<丙酮<水，它与所有溶剂体系的实验温度和溶剂组成呈正相关。对于极性质子溶剂，影响溶解度的关键因素是碳链的长度和溶剂性质。通过KAT-LSER模型分析了溶剂-溶剂和溶剂-溶质之间的分子间相互作用对溶解度行为的影响。修改后的Apelblat，Jouyban-Acree和Apelblat-Jouyban-Acree模型用于关联溶解度数据，并且发现由三个热力学模型计算出的值与实验数据吻合良好。