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Development of Novel Pesticides Targeting Insect Chitinases: A Minireview and Perspective.
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2020-04-08 , DOI: 10.1021/acs.jafc.0c00888 Wei Chen 1 , Qing Yang 1, 2
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2020-04-08 , DOI: 10.1021/acs.jafc.0c00888 Wei Chen 1 , Qing Yang 1, 2
Affiliation
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Chitinase (EC 3.2.1.14) is an enzyme to breakdown β-1,4-glycosidic bonds in chitin and chitooligosaccharides. The loss of chitinase enzymatic activity in insects results in severe exoskeleton defects and lethality at all developmental stages, indicating that insect chitinases can be promising pesticide targets. However, there are no pesticides known to target chitinases. This perspective will focus on the latest research progress of insect chitinases, paying special attention to crystal structures and chemical biology advances in the field. The physiological importance and unique structural features of insect chitinases may ensure the development of new pesticides through a novel acting mode.
中文翻译：
针对昆虫几丁质酶的新型农药的开发：Minireview和观点。
几丁质酶（EC 3.2.1.14）是一种分解几丁质和壳寡糖中β-1,4-糖苷键的酶。昆虫中几丁质酶酶活性的丧失导致严重的外骨骼缺陷和在所有发育阶段的致死性，这表明昆虫几丁质酶可以成为有希望的杀虫剂靶标。但是，尚无针对几丁质酶的农药。该观点将集中于昆虫几丁质酶的最新研究进展，特别关注该领域的晶体结构和化学生物学进展。昆虫几丁质酶的生理重要性和独特的结构特征可以通过一种新的作用方式确保新农药的开发。
更新日期：2020-04-24
中文翻译：
针对昆虫几丁质酶的新型农药的开发：Minireview和观点。
几丁质酶（EC 3.2.1.14）是一种分解几丁质和壳寡糖中β-1,4-糖苷键的酶。昆虫中几丁质酶酶活性的丧失导致严重的外骨骼缺陷和在所有发育阶段的致死性，这表明昆虫几丁质酶可以成为有希望的杀虫剂靶标。但是，尚无针对几丁质酶的农药。该观点将集中于昆虫几丁质酶的最新研究进展，特别关注该领域的晶体结构和化学生物学进展。昆虫几丁质酶的生理重要性和独特的结构特征可以通过一种新的作用方式确保新农药的开发。
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