Microketides A and B, Polyketides from a Gorgonian-Derived Microsphaeropsis sp. Fungus.,Journal of Natural Products

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Microketides A and B, Polyketides from a Gorgonian-Derived Microsphaeropsis sp. Fungus.
Journal of Natural Products ( IF 3.3 ) Pub Date : 2020-04-03 , DOI: 10.1021/acs.jnatprod.0c00144
Yun-Feng Liu _{1,

2} , Ya-Hui Zhang _{1,

2} , Chang-Lun Shao _{1,

3} , Fei Cao ₂ , Chang-Yun Wang _{1,

3}

Affiliation

Microketides A and B (1 and 2), a pair of new C-11 epimeric polyketides, were obtained from the gorgonian-derived fungus Microsphaeropsis sp. RA10-14 collected from the South China Sea. The absolute configurations of 1 and 2 were assigned by the modified Mosher's method, TDDFT-ECD, and NMR calculations. Compounds 1 and 2 were evaluated for antibacterial, antifungal, and growth inhibition of marine phytoplankton activities. Microketide A (1) exhibited promising inhibitory activity against Pseudomonas aeruginosa, Nocardia brasiliensis, Kocuria rhizophila, and Bacillus anthraci with the same MIC value as ciprofloxacin (0.19 μg/mL).

更新日期：2020-04-03

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