3D-Printing of Structure-Controlled Antigen Nanoparticles for Vaccine Delivery.,Biomacromolecules

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3D-Printing of Structure-Controlled Antigen Nanoparticles for Vaccine Delivery.
Biomacromolecules ( IF 5.5 ) Pub Date : 2020-04-02 , DOI: 10.1021/acs.biomac.9b01775
Akihiro Nishiguchi ₁ , Fumiaki Shima ₂ , Smriti Singh ₁ , Mitsuru Akashi ₂ , Martin Moeller ₁

Affiliation

Targeted delivery of antigens to immune cells using micro/nanocarriers may serve as a therapeutic application for vaccination. However, synthetic carriers have potential drawbacks including cytotoxicity, low encapsulation efficiency of antigen, and lack of a morphological design, which limit the translation of the delivery system to clinical use. Here, we report a carrier-free and three-dimensional (3D)-shape-designed antigen nanoparticle by multiphoton lithography-based 3D-printing. This simple, versatile 3D-printing approach provides freedom for the precise design of particle shapes with a nanoscale resolution. Importantly, shape-designed antigen nanoparticles with distinct aspect ratios show shape-dependent immune responses. The 3D-printing approach for the rational design of nanomaterials with increasing safety, complexity, and efficacy offers an emerging platform to develop vaccine delivery systems and mechanistic understanding.

中文翻译：

用于疫苗输送的结构受控抗原纳米颗粒的3D打印。

使用微/纳米载体将抗原靶向递送至免疫细胞可以用作疫苗的治疗应用。然而，合成载体具有潜在的缺点，包括细胞毒性，抗原的包封效率低和缺乏形态学设计，这限制了递送系统向临床用途的翻译。在这里，我们报告通过多光子光刻基于3D打印的无载体和三维（3D）形状设计的抗原纳米粒子。这种简单，通用的3D打印方法为纳米级分辨率的颗粒形状的精确设计提供了自由。重要的是，具有不同长宽比的形状设计的抗原纳米颗粒显示出形状依赖性免疫反应。3D打印方法可合理设计纳米材料，并提高安全性，复杂性，

更新日期：2020-04-02

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