Gold-Catalyzed Oxidative Cascade Cyclization of 1,3-Diynamides: Polycyclic N-Heterocycle Synthesis via Construction of a Furopyridinyl Core,Organic Letters

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Gold-Catalyzed Oxidative Cascade Cyclization of 1,3-Diynamides: Polycyclic N-Heterocycle Synthesis via Construction of a Furopyridinyl Core
Organic Letters ( IF 4.9 ) Pub Date : 2020-04-03 , DOI: 10.1021/acs.orglett.0c01086
Jibing Liu _{1,

2} , Lei Zhu _{1,

2} , Wan Wan _{1,

2} , Xueliang Huang _{1,

2}

Affiliation

A facile and practical approach to construct a furopyridinyl motif through a gold-catalyzed cascade cyclization of easily accessible diynamides is described. This strategy offers a straightforward approach to furo[2,3-c]isoquinoline and 6H-furo[3′,2′:5,6]pyrido[3,4-b]indole derivatives. The reaction could build up four new bonds and two additional heteroaromatic rings via a single operation. The heterocyclic products show promising blue luminous performance with fluorescence quantum yields up to 75%.

中文翻译：

金催化的1，3-二乙酰胺的氧化级联环化：通过呋喃吡啶基核心的建设多环N杂环合成。

描述了一种通过金催化的容易获得的二炔酰胺的级联环化来构建呋喃吡啶基基序的简便实用的方法。该策略为呋喃[2,3- c ]异喹啉和6 H-呋喃[3'，2'：5,6]吡啶[3,4- b ]吲哚衍生物提供了直接的方法。该反应可通过一次操作建立四个新键和两个额外的杂芳环。杂环产品显示出令人鼓舞的蓝色发光性能，荧光量子产率高达75％。

更新日期：2020-04-24

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