Oxidative Kinetic Resolution of Acyclic Amines Based on Equilibrium Control,Organic Letters

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Oxidative Kinetic Resolution of Acyclic Amines Based on Equilibrium Control
Organic Letters ( IF 4.9 ) Pub Date : 2020-04-02 , DOI: 10.1021/acs.orglett.0c00887
Kodai Saito _{1,

2} , Hiromitsu Miyashita ₁ , Yui Ito ₃ , Masahiro Yamanaka ₃ , Takahiko Akiyama ₁

Affiliation

An oxidative kinetic resolution of racemic acyclic amines was developed using an imine derivative as the resolving reagent and chiral phosphoric acid as the catalyst to give enantiomers in good yields with high to excellent enantioselectivities. The key to success of the title reaction was the equilibrium control by adjusting the ratio of the resolving reagent, and unique enantiodivergence was observed depending on the equilibrium displacement.

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