Palladium-Catalyzed Mizoroki–Heck Reaction of Nitroarenes and Styrene Derivatives,Organic Letters

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Palladium-Catalyzed Mizoroki–Heck Reaction of Nitroarenes and Styrene Derivatives
Organic Letters ( IF 4.9 ) Pub Date : 2020-04-02 , DOI: 10.1021/acs.orglett.0c00983
Toshimasa Okita ₁ , Kitty K. Asahara ₁ , Kei Muto ₁ , Junichiro Yamaguchi ₁

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We have developed a Mizoroki–Heck reaction of nitroarenes with alkenes under palladium catalysis. The use of a Pd/BrettPhos catalyst promoted the alkenylation, whereas other catalysts led to a decrease in the product yield. In addition to nitroarenes, nitroheteroarenes were also applicable to the present reaction. The combination of a nucleophilic aromatic substitution (S_NAr) with the denitrative alkenylation produced a multifunctionalized arene in a one-pot operation.

中文翻译：

钯催化的硝基芳烃和苯乙烯衍生物的咪唑罗基-赫克反应

我们已经开发了钯催化下硝基芳烃与烯烃的Mizoroki-Heck反应。Pd / BrettPhos催化剂的使用促进了烯基化，而其他催化剂导致产物收率下降。除硝基芳烃外，硝基杂芳烃也适用于本反应。亲核芳族取代（S的组合_Ñ AR）与denitrative烯基化产生在单罐操作的多官能化的芳烃。

更新日期：2020-04-24

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