A chiral CpRh^III-catalyzed asymmetric C–H activation reaction of N-methoxybenzamides with quinones has been developed to efficiently forge chiral tricyclic hydrophenanthridinone scaffolds in ≤88% yield and ≤94% ee. With this methodology as the key step, an enantioenriched dihydrolycoricidine derivative has been synthesized in 64% overall yield in five steps.

中文翻译：

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铑（III）催化N-甲氧基苯甲酰胺与醌的不对称CH活化及其在二氢可可啶类似物的不对称合成中的应用。

已开发出手性CpRh ^III催化的N-甲氧基苯甲酰胺与醌的不对称C–H活化反应，可有效地锻造手性三环对苯二甲酮骨架，产率≤88％，ee≤94％。以该方法学为关键步骤，已通过五个步骤以64％的总收率合成了对映体富集的二氢可可可啶衍生物。