Background Akathisia is a rather common extrapyramidal side effect of antipsychotic drugs and antidepressants, often resulting in severe discomfort for patients. However, due to the diversity of symptoms, it is often overlooked. We hereby report a case with akathisia that mainly appeared in an amputated leg. Case presentations A 60-year-old woman, who had undergone external hemipelvectomy for a recurrent soft tissue sarcoma, was referred to the Department of Psycho-Oncology due to worsening anxiety and restlessness. She was not unconscious or disoriented. Her chief complains included restlessness, an itching sensation in the area corresponding to the amputated left leg, and a feeling as if the lost left leg were raising itself. Detailed examination revealed that she had been administered 10 mg per day of oral prochlorperazine maleate for nausea induced by the oxycodone that had been prescribed to control post-operative pain. Akathisia was suspected and prochlorperazine maleate treatment was discontinued. All the symptoms were alleviated on the next day, and disappeared in 3 days. Eventually, she was diagnosed with akathisia. Conclusions This case indicates that the symptoms associated with akathisia can occur in an amputated extremity. Considering two previous reports of "phantom dyskinesia", extrapyramidal syndromes may result in unusual presentations if occurring in an amputated extremity. Not only should the use of antipsychotic drugs and antidepressants be carefully considered, but also closer observation of psychological symptoms is required after prescription of these drugs because the clinical presentation of akathisia can be various and confusing due to modifications caused by other factors as in this case.

中文翻译：

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肉瘤患者截肢中的“幻影静坐不能”：病例报告。

背景 静坐不能是抗精神病药物和抗抑郁药相当常见的锥体外系副作用，通常会导致患者严重不适。然而，由于症状的多样性，它往往被忽视。我们特此报告一例主要出现在截肢的静坐不能。病例介绍 一名 60 岁的女性因复发性软组织肉瘤接受了半骨盆外切除术，由于焦虑和不安的恶化，她被转诊到心理肿瘤科。她没有失去知觉或迷失方向。她的主要抱怨包括坐立不安、与截肢的左腿对应的区域有瘙痒感，以及失去的左腿好像在抬起自己的感觉。详细检查显示，她每天口服 10 毫克马来酸丙氯拉嗪，以治疗由用于控制术后疼痛的羟考酮引起的恶心。怀疑静坐不能并停止马来酸丙氯拉嗪治疗。次日症状全部缓解，3天后消失。最终，她被诊断出患有静坐不能。结论 本例表明与静坐不能相关的症状可出现在截肢。考虑到之前关于“幻肢运动障碍”的两份报告，如果发生在截肢的肢体中，锥体外系综合征可能会导致异常表现。不仅应该仔细考虑使用抗精神病药物和抗抑郁药，