Litomosoides sigmodontis is the only filarial nematode where the full life cycle, from larval delivery to the skin through to circulating microfilaria, can be completed in immunocompetent laboratory mice. It is thus an invaluable tool for the study of filariasis. It has been used for the study of novel anti‐helminthic therapeutics, the development of vaccines against filariasis, the development of immunomodulatory drugs for the treatment of inflammatory disease and the study of basic immune responses to filarial nematodes. This review will focus on the latter and aims to summarize how the L sigmodontis model has advanced our basic understanding of immune responses to helminths, led to major discoveries in macrophage biology and provided new insights into the immunological functions of the pleural cavity. Finally, and most importantly L sigmodontis represents a suitable platform to study how host genotype affects immune responses, with the potential for further discovery in myeloid cell biology and beyond.

中文翻译：

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近交实验室小鼠对Sigmodontis sigmodontis的免疫反应：在骨髓细胞生物学中发现的途径。

乙状结肠线虫（Sitomosoides sigmodontis）是唯一能够在具有免疫能力的实验室小鼠中完成从幼虫递送到皮肤直至循环微丝aria的整个生命周期的丝虫线虫。因此，它是研究丝虫病的宝贵工具。它已被用于研究新型抗蠕虫药，开发针对丝虫病的疫苗，开发用于治疗炎性疾病的免疫调节药物以及研究对丝虫线虫的基本免疫反应。这篇评论将重点放在后者上，目的是总结L sigmodontis该模型提高了我们对蠕虫免疫应答的基本理解，促成了巨噬细胞生物学的重大发现，并为了解胸膜腔的免疫功能提供了新的见解。最后，最重要的是，L sigmodontis代表了一个合适的平台，用于研究宿主基因型如何影响免疫反应，并有可能在髓样细胞生物学及其他领域进一步发现。