Altered morphology and function of the peripheral nociceptive system in the offspring of diabetic rats,International Journal of Developmental Neuroscience

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Altered morphology and function of the peripheral nociceptive system in the offspring of diabetic rats
International Journal of Developmental Neuroscience ( IF 1.7 ) Pub Date : 2020-03-06 , DOI: 10.1002/jdn.10023
Taís Campos Lima ₁ , Júlia Borges Paes Lemes ₁ , Tauane Franco Pinheiro Alves Capop ₁ , Lorena Borges de Lima ₁ , Celina Monteiro da Cruz Lotufo ₁

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The aim of this study was to determine whether maternal diabetes induced by alloxan injection in the first gestational day of female Wistar rats interferes with the development of the nociceptive peripheral system of the offspring. Behavioral and histologic analysis was performed using the adult offspring of diabetic and control rats. It was found that the offspring of diabetic rats were more sensitive to thermal stimulation and showed an altered response to carrageenan‐induced inflammatory hyperalgesia. The histological analysis showed an increased proportion of nociceptive neurons, while the population of non‐nociceptive myelinated neurons was reduced. Therefore, exposition to hyperglycemia and/or hyperinsulinemia in uterus, caused by a diabetic mother, might result in altered nociceptive sensations in the offspring throughout life.

中文翻译：

糖尿病大鼠后代外周痛觉系统的形态和功能改变

本研究的目的是确定在雌性 Wistar 大鼠的第一个妊娠日注射四氧嘧啶引起的母体糖尿病是否会干扰后代伤害性外周系统的发育。使用糖尿病大鼠和对照大鼠的成年后代进行行为和组织学分析。结果发现，糖尿病大鼠的后代对热刺激更敏感，并对角叉菜胶诱导的炎症性痛觉过敏反应发生改变。组织学分析显示，伤害性神经元的比例增加，而非伤害性有髓神经元的数量减少。因此，暴露于由糖尿病母亲引起的子宫内高血糖和/或高胰岛素血症可能会导致后代终生改变伤害感受。

更新日期：2020-03-06

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