Magnesium may be used as an adjunctive analgesic for perioperative pain management because of its antinociceptive properties. This study investigated the analgesic efficacy of intraperitoneal ropivacaine combined with magnesium sulfate in canine ovariohysterectomy. Forty‐five dogs sedated with acepromazine/meperidine and anesthetized with propofol/isoflurane were randomly distributed into three treatments, administered intraperitoneally (n  = 15 per group): saline solution (group S), 0.25% ropivacaine (3 mg/kg) alone (group R), or in combination with magnesium sulfate (20 mg/kg, group R‐Mg). Intravenous fentanyl was given to control cardiovascular responses to surgical stimulation. Postoperative pain was assessed using an Interactive Visual Analog Scale (IVAS), the short form of the Glasgow Composite Pain Scale, and mechanical nociceptive thresholds. Morphine/meloxicam was administered as rescue analgesia. Intraoperatively, the R‐Mg group required less fentanyl (p  = .02) and exhibited higher incidence of hypotension (systolic arterial pressure <90 mm Hg, p  = .006) compared with the S group. Lower IVAS pain scores were recorded during the first hour in the R‐Mg group than the other groups (p  = .007–.045). Postoperative rescue analgesia did not differ between groups. Intraperitoneal magnesium sulfate administration, in spite of decreasing intraoperative opioid requirements, increased the incidence of hypotension with minimal evidence of postoperative analgesic benefits.

中文翻译：

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在腹腔罗哌卡因中添加硫酸镁，用于犬卵巢子宫切除术中的围手术期镇痛。

由于镁具有抗伤害感受特性，因此可以用作围手术期疼痛控制的辅助镇痛药。这项研究调查了腹腔罗哌卡因联合硫酸镁在犬卵巢子宫子宫切除术中的镇痛效果。将45只用乙酰丙嗪/哌啶镇静并用异丙酚/异氟醚麻醉的狗随机分配到三种治疗方法中，腹膜内给药（n =每组15个）：盐溶液（S组），0.25％罗哌卡因（3 mg / kg）单独使用（R组）或与硫酸镁组合使用（20 mg / kg，R-Mg组）。静脉注射芬太尼可控制心血管对手术刺激的反应。使用交互式视觉模拟量表（IVAS），格拉斯哥综合疼痛量表的简写形式和机械伤害阈值评估术后疼痛。吗啡/美洛昔康可作为抢救性镇痛药。 与S组相比，术中R–Mg组需要更少的芬太尼（p  = .02），并且低血压发生率更高（收缩动脉压<90 mm Hg，p = .006）。R‐Mg组在头1小时内记录的IVAS疼痛评分低于其他组（p = .007–.045）。两组之间的术后抢救镇痛没有差异。尽管术中阿片类药物的需求量减少，腹膜内施用硫酸镁仍增加了低血压的发生率，而术后止痛效果却很少。