PURPOSE The incidence and time of onset of acute chemotherapy-induced peripheral neuropathy (ACIPN) caused by oxaliplatin remain unclarified. Hence, we investigated the prevalence, onset time, and location of ACIPN symptoms in patients with colorectal cancer (CRC) receiving oxaliplatin without cold stimulation. METHODS The study cohort comprised patients receiving oxaliplatin for CRC at our hospital between April 2017 and August 2018. Patients were instructed not to touch and/or drink cold things and were monitored for ACIPN symptoms in the hospital for 24 h after chemotherapy. ACIPN symptoms that appeared > 24 h after chemotherapy were recorded at the next visit. Symptom appearance time was defined as the duration from the administration of chemotherapy until the appearance of paresthesia classified as grade 1 using the Common Terminology Criteria for Adverse Events. RESULTS Forty-five patients received chemotherapy, comprising 23 men and 22 women, aged 67 years (29-88 years). The location of ACIPN was the fingers in 55.6% of cases, pharynx in 26.7%, perioral region in 24.4%, and feet in 6.7%. The average duration from oxaliplatin administration to symptom development was 182 min (range 62-443 min) for the fingers, 291 min (176-432 min) for the pharynx, 311 min (127-494 min) for the perioral region, and 297 min (234-355 min) for the feet. Pharyngeal symptoms were more common in patients older than 65 years than in those younger than 65 years. CONCLUSIONS The incidence and time of the onset of ACIPN caused by oxaliplatin varies between the body and regions.

中文翻译：

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奥沙利铂给药引起的急性化疗引起的周围神经病变而无冷刺激。

目的尚不清楚由奥沙利铂引起的急性化疗诱导的周围神经病（ACIPN）的发病率和发作时间。因此，我们调查了接受奥沙利铂而不冷刺激的结直肠癌（CRC）患者中ACIPN症状的发生率，发病时间和位置。方法该研究队列包括2017年4月至2018年8月在我院接受奥沙利铂治疗CRC的患者。患者被指示不要触摸和/或喝冷的东西，并在化疗后24小时内在医院接受ACIPN症状监测。在下一次就诊时记录了化疗后> 24小时出现的ACIPN症状。症状出现时间定义为从化疗开始到使用不良事件通用术语标准归为1级感觉异常的持续时间。结果45例患者接受了化疗，包括23名男性和22名女性，年龄67岁（29-88岁）。ACIPN的位置是手指，占55.6％，咽部占26.7％，口周区域占24.4％，脚占6.7％。从服用奥沙利铂到症状发展的平均时间，手指为182分钟（范围为62-443分钟），咽部为291分钟（176-432分钟），口周区域为311分钟（127-494分钟），以及297分钟分钟（234-355分钟）。65岁以上患者的咽部症状比65岁以下的患者更常见。